A new experimental system sheds light on how memory loss may occur

first_imgBrain activity in the hippocampus changes after silencing the enthorinal cortex“We know that the hippocampal neurons generate pulses of activity when the animal is in a particular space,” said co-corresponding author Dr. Daoyun Ji, assistant professor of molecular & cell biology at Baylor.To measure the electrical activity in the hippocampus, the researchers inserted tiny probes – thinner than a human hair – into the brains of mice. “We inserted the probes into the hippocampus where they could detect the electrical signal generated by active neurons. We recorded this signal while the animal explored its surroundings. As the mouse learned its environment, we picked up the electrical pulses produced by the neurons – up to 50 neurons simultaneously – so that we could examine the pattern that emerged. When the animal was in one area of the room, a particular brain pattern emerged. The pattern changed as the animal moved to another area. We could predict where the animal was by looking at its pattern of brain activity,” said Ji.When the researchers turned off the entorhinal cortex with ivermectin, they saw the pattern of electrical signals in the hippocampus changed. Signals that had previously been associated with a particular location now became active in a different part of the room. “We found that the hippocampus had remapped, the memory code was scrambled,” said Ji. But would mice whose mental map had rearranged itself also lose their memory for the location they learned before re-mapping?To answer this question, the researchers trained mice to find a hidden escape platform submerged in a water maze using visual clues. Then some of the mice received ivermectin to inactivate the entorhinal cortex, while others did not. “The mice had been trained for 7 to 10 days, so they knew where to go to escape the pool. But when we turned off the entorhinal cortex, their hippocampal map got scrambled and the animals couldn’t remember how to exit the pool,” said Ji.“Our findings put us one step closer to understanding how our hippocampus may be required not only to learn a new environment, but also to remember it later,” said Jankowsky. “The system we used to silence neurons with ivermectin adds to a growing set of genetic tools created over the last 10 years to probe brain function. Because ivermectin is both safe and inexpensive, this particular system can be used for longer periods of inactivation appropriate for studying chronic conditions like Alzheimer’s or Parkinson’s. That’s the thing I am most excited about with this work,” said Jankowsky. Share on Facebook Email Share Share on Twittercenter_img Pinterest LinkedIn Two interconnected brain areas – the hippocampus and the entorhinal cortex – help us to know where we are and to remember it later. By studying these brain areas, researchers at Baylor College of Medicine, Rice University, The University of Texas MD Anderson Cancer Center and the National Cancer Institute have uncovered new information about how dysfunction of this circuit may contribute to memory loss in Alzheimer’s disease. Their results appear in Cell Reports.“We created a new mouse model in which we showed that spatial memory decays when the entorhinal cortex is not functioning properly,” said co-corresponding author Dr. Joanna Jankowsky, associate professor of neuroscience at Baylor. “I think of the entorhinal area as a funnel. It takes information from other sensory cortices – the parts of the brain responsible for vision, hearing, smell, touch, and taste – and funnels it into the hippocampus. The hippocampus then binds this disparate information into a cohesive memory that can be reactivated in full by recalling only one part. But the hippocampus also plays a role in spatial navigation by telling us where we are in the world. These two functions converge in the same cells, and our study set out to examine this duality.”The new mouse model was genetically engineered to carry a particular surface receptor on the cells of the entorhinal cortex. When this receptor was activated by administering the drug ivermectin to the mice, the cells of the entorhinal cortex silenced their activity. They stopped funnelling information to the hippocampus. This system allowed the scientists to turn off the entorhinal cortex, and to determine how this affected hippocampal function.last_img read more

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NFL Uniforms (Vikings)

first_imgOnWis97 Link to post Link to post 0 By ba43, July 14, 2006 in Sports Logo News 0 Sign in to follow this   Share this post OnWis97 132 Posted July 17, 2006 Link to post 0 The collars get cut off as well. The bottom portion is the same color as the jersey. All Activity 573 All Activity Go To Topic Listing Forums Home Location:Pensacola, FL 4,436 573 My alone time is for everyone’s safety Sports Logo News ba43 Members This topic is now closed to further replies. Like these!!! Followers 0 Geoff Followers 0 Share on other sites Members Link to post 0 KCScout76 Members Sports Logos Share on other sites 0 Share on other sites NFL Uniforms (Vikings) ba43 Sports Logo News ba43 Posted July 15, 2006 14,934 posts Members 16 posts 4,436 8,640 posts You forgot to update the helmet. Other than that these arwe great. 573 Sign in to follow this   0 Here’s what I did for the Vikings and their new uniforms. Again, these are used by our Fantasy Football league that only uses NFL team names. I made Share on other sites Posted July 15, 2006 It should always be Christmas in New Jersey 16 posts 0 132 Share this post Members SportsLogos.Net 0 0 132 0 Link to post You’re Khilling me, Smalls. KCScout76 Sports Logos Forums Home Location:Lee’s Summit, Missouri Thanks again for the feedback. I’ll try to add that feature. I see it now on the pictures I have.Again, this is only for use on a FF league that I run so accuracy is going to not be that relevant when you only have a 100×100 pixel space to put these in on the team pages.I just hope to inspire somebody with better skills than I to finish what’s missing on the NFL pages here on sportslogos.net.New Vikings and new Browns, 49ers road and alternates, All Chargers, Titans, Buccaneers, Redskins and Rams need to be completed. Share this post 0 7,012 posts ba43 NFL Uniforms (Vikings) Posted July 14, 2006 Posted July 14, 2006 Recommended Posts 4,436 Share this post SportsLogos.Net Share this post Share on other sites Geoff NFL Uniforms (Vikings)last_img read more

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Wellington to host Clearwater tonight in AV-CTL DIV action; potato bar featured

first_imgRose Hill1152 Boys AV-CTL DIV standings Andale at Rose Hill Clearwater0223 Andale2041 Fri., Jan. 10 Upcoming league schedule:  Girls AV-CTL DIV standings Andale1123 Andale at Nickerson Rose Hill at Collegiate Clearwater at Mulvane Close Forgot password? Please put in your email: Send me my password! Close message Login This blog post All blog posts Subscribe to this blog post’s comments through… RSS Feed Subscribe via email Subscribe Subscribe to this blog’s comments through… RSS Feed Subscribe via email Subscribe Follow the discussion Comments Logging you in… Close Login to IntenseDebate Or create an account Username or Email: Password: Forgot login? Cancel Login Close WordPress.com Username or Email: Password: Lost your password? Cancel Login Dashboard | Edit profile | Logout Logged in as Admin Options Disable comments for this page Save Settings You are about to flag this comment as being inappropriate. Please explain why you are flagging this comment in the text box below and submit your report. The blog admin will be notified. Thank you for your input. There are no comments posted yet. Be the first one! Post a new comment Enter text right here! Comment as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Submit Comment Subscribe to None Replies All new comments Comments by IntenseDebate Enter text right here! Reply as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Cancel Submit Comment Subscribe to None Replies All new comments Collegiate2041 Wellington2042 LeagueOverallcenter_img Mulvane1125 WLWL Collegiate0223 Clearwater1132 WLWL Rose Hill1134 Mulvane1143 LeagueOverall Tues. Jan. 14 Clearwater at Wellington Sumner Newscow report — Wellington is hosting Clearwater tonight in Ark Valley Chisholm Trail League Div. IV action. There will be a potato bar for $5 at the games tonight hosted by the leadership team.Also, the varsity games will be live-streamed thanks to Impact Bank of Wellington. To view the games tonight, click here.The AV-CTL DIV varsity basketball standings are as follows: W. Collegiate at Wellington Wellington0233 Follow us on Facebook.Follow us on Twitter.last_img read more

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Modern facade and facilities too

first_imgBy EMMA SUN EMERALD Primary School will be looking brand new by next year after receiving $6 million in State…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.last_img

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Williams powers Leafs to 1-0 victory over defending KIJHL Champs

first_imgThe defending KIJHL champs made a push in the third, out shooting Nelson 17-10.However, Williams was unbeatable securing the two points for the Leafs.Beaver Valley finished the game with a 38-26 shots advantage.Nelson returns to the NDCC Arena Saturday to host the Kimberley Dynamiters in a Kootenay Conference encounter at 7 p.m.Meanwhile, Beaver Valley hosts Fernie Ghostriders as the Hawks raise another KIJHL Banner to the rafters in the Beaver Valley Arena after capturing the title last season.In other Murdoch Division action, Logan Hascarl scored the winning goal in the second overtime to spark the Grand Forks Border Bruins to a 3-2 victory over the Ghostriders in Fernie.Evan Loura and Reece Tambellini also scored for Grand Forks. Trevor Dilauro stopped 51 shots to register the shutout for Spokane.Spokane Braves defeated Creston Valley Thunder Cats 3-0 in the Lilac City. If goaltending was the Achilles’ heel for the Nelson Leafs last season, it appears to be rock solid to begin the new Kootenay International Junior Hockey League campaign.Josh Williams stopped 38 shots to backstop the Nelson Leafs to a 1-0 victory over the Beaver Valley Nitehawks Friday night at the NDCC Arena.The contest was the opener for both teams as the KIJHL kicked off its 2017-18 season.Williams, who decided to return to the Green and White after spending time Junior A, was rock solid in the opening frame as the Leafs struggled to find any momentum as the Nitehawks held a 14-3 shots advantage during the first period.In the second period, Alberta native David Sanchez scored the only Nelson would need as the 18-year-old forward beat Owen Sikes in the Beaver Valley nets for the game’s only marker.last_img read more

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Galway GAA Results – Gaelic Football

first_imgDivision 2Killererin 0-9 Moycullen 0-6Caherlistrane 1-18 Salthill/Knocknacarra 2-11Caltra 1-13 Kilconly 2-8 Division 4St. Brendan’s 2-13 Claregalway       1-12 LeaguesDivision 6Kilconly 2-11 Corofin 1-7 County Leagues:Division 1St. James 0-9 Killannin 0-7Milltown 0-9 Annaghdown 0-7Cortoon Shamrocks 4-9 Mountbellew/Moylough 1-10Corofin 1-14 Micheál Breathnach 2-7 Junior “A”:Na Piarsaigh  0-17 Fr. Griffin’s/Éire Óg 1-11Barna 1-17 Oughterard 2-10 Menlough play Oranmore/Maree in the Final Minor:“A” Barna 4-14 An Spideal 1-11“A” Salthill/Knocknacarra 3-11 Moycullen 1-12“B” St. Michaels 1-14 Micheál Breathnach 1-13“B” Leitir Mór 3-11 St. James 2-8 Menlough 1-13 Athenry 2-7 Division 8 LeagueOranmore/Maree 4-19 Ballinasloe 1-3Padraig Pearses 2-10 Loughrea 1-5print WhatsApp Facebook Twitter Email Cahill Cup – Semi-Final-Replay; West GPC:Championships:Junior:Salthill/Knocknacarra 3-17 An Cheathru Rua 1-2 Junior “A”:Meelick Eyrecourt 3-8 Dunmore MacHales 2-7 Minor:“A” Monivea/Abbey 1-8 Mount Bellew/Moylough 1-6“A” Corofin 2-19 Oranmore/Maree 4-6                         AET“A” Annaghdown 2-8 Kilkerrin/Clonberne 1-4“B” Tuam Stars 5-13 Athenry 2-12“B” Menlough 7-12 Loughrea 0-10“B” St. Gabriels 4-9 St. Brendan’s 2-14“B” Glenamaddy w/o Ballinasloe scr“C” Kilconly 6-8 Cortoon Shamrocks 2-8“C” Killererin 1-12 Milltown 0-8“C” Williamstown 1-12 Caltra 0-10 North GPCChampionships:Junior:St. Gabriels 2-14 Corofin 0-8 Division 3Monivea/Abbey 2-14 An Spideal 1-10last_img read more

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Big weekend of Club Hurling Championship action

first_imgA busy weekend of senior and Intermediate club championship action in Galway gets under way this evening (Friday) with two games down for decision. In the Senior A Championship, Liam Mellows play Craughwell at 7pm in Athenry while in the Intermediate Championship, Oranmore Maree play Meelick Eyrecourt at 7pm in Loughrea. The fixtures for the rest of the weekend and the current standings in both competitions are: Saturday SundaySenior A Hurling Championship – Group 1(Round: Round 3), Venue: Duggan Park , Tommy Larkins V Mullagh14:00,  Ref: John KeaneSenior A Hurling Championship – Group 2Sarsfields V Pádraig Pearses 3.30pm BallinasloeGort V St Thomas 6pm AthenrySenior B Hurling Championship – Group 1Ardrahan V Carnmore 4.30pm Athenry print WhatsApp Facebook Twitter Emailcenter_img Senior A Hurling Championship – Group 1Loughrea V Cappataggle 6.30pm BallinasloeSenior A Hurling Championship – Group 2Portumna V Turloughmore 1pm BallinasloeSenior B Hurling Championship – Group 1Tynagh/Abbey-Duniry V Clarinbridge 5pm AthenryBeagh V Castlegar 5pm LoughreaSenior B Hurling Championship – Group 2Ahascragh/Fohenagh V Abbeyknockmoy 2pm AthenryAthenry V Kilnadeema-Leitrim 5pm BallinasloeKillimordaly V Moycullen 7pm Pearse Stadium Intermediate Hurling Championship – Group 1Clarinbridge V Kinvara 3.30pm AthenryIntermediate Hurling Championship – Group 2Killimor V An Spidéal 3.30pm LoughreaAnnaghdown V Kilbeacanty 4pm CraughwellBallinderreen V Rahoon-Newcastle 6pm Carnmorelast_img read more

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Islanders Come up Short at SMU

first_imgThe Islanders (3-1) lost a tough doubles point on courts one and two as the sophomore duo of Paul Cook and Kevin Bettendroffer dropped their first loss of the season at No. 2 doubles. The pair came up short 6-1 to Nate Lammons and Arkadijs Slobodkins. SMU then captured the doubles point after Arturs Kazijevs and Markus Kerner defeated the senior-junior pair of Peter Nagy and Guillaume Rauseo, 6-4, at No. 1 doubles. After picking up their first doubles win of the season on Tuesday, Arthur Bedel and Mitchell Cook were trailing SMU’s Samm Butler and Tony Russell, 5-2, at No. 3 doubles when the point was clinched.  The Mustangs earned their fifth and final point of the day in No. 3 singles after Butler rallied back against Ricardo Mayagoitia after being a set and a break down. Mayagoitia garnered the first set 6-4, before Butler answered back with a 6-4 second-set win and 6-3 third-set victory. SMU carried its momentum over into singles play to take a 3-0 lead after picking up straight-set wins on courts five and six. Javier Pujol fell 6-1, 6-2 to Slobodkins in No. 5 singles for his first loss of the season. P. Cook also came up short in No. 6 singles, 6-3, 6-4 to Charles Nettlefold. SMU battled back from a set and a break down at three and four to claim the victory at home against a scrappy Islander team. At No. 4 singles, Rauseo bested Lammons 6-3, in the first set before Lammons rallied back to top Rauseo 6-4 in the second and 6-1 in the third to give SMU its clinching fourth point.  The final four singles matches featured three-setters. Bettendroffer put the Islanders on the board with a come-from-behind victory in No. 2 singles. The sophomore dropped the first set 6-1, before bouncing back to edge Kerner 7-5 in the second set. In the third, Bettendroffer closed out a 6-1 win for his third win of the season.center_img The highlight of the night was Nagy’s thrilling match at No. 1 singles. After dropping the first set, the senior battled back with some great shots in the second and third to win, 1-6, 6-3, 7-5 over Kazijevs, who was ranked in the ITA national rankings last season. SMU 5, Texas A&M-Corpus Christi 2DALLAS, Texas – The Texas A&M-Corpus Christi men’s tennis team suffered a heartbreaking 5-2, loss tonight against a very tough SMU squad at the SMU Indoor Tennis Complex. The Mustangs (7-1) clinched the doubles point before securing four of the six singles matches. The men will remain on the road to face Texas Tech in Lubbock, Texas on Saturday, Feb. 14, at 1 p.m.last_img read more

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K5, The Autonomous Security Robot, Is Now On The Beat

first_imgWorking as a security guard can be a dangerous and thankless job. Now Knightscope wants robots to do it for us. The Mountain View, Calif., startup has been building and testing a robot model known as the K5 for this purpose since 2013, MIT Technology Review reports. Now the robot fleet is advanced enough to patrol Microsoft’s Silicon Valley campus. See also: R2-D2? Dalek? Actually, It’s A Pre-Cog RobocopAt five feet tall and 300 pounds, the K5 is an ambulatory robot with semi-human proportions. Sleek and smooth, it is supposed to look friendly from a distance, but intimidating close up. It doesn’t carry weapons and it can’t hurt people, but it will beep ominously if you try to detain it while sending an alert to a remote monitoring center. (Early models still have a serious vulnerability—push them over and they can’t get up without assistance.)On the other hand, the K5 can also be a friendly presence. If you need help, you can press a button on the top of the robot’s head to summon a human operator. “This takes away the monotonous and sometimes dangerous work, and leaves the strategic work to law enforcement or private security, depending on the application,” Knightscope cofounder and vice president of sales and marketing Stacy Stephens told MIT. (Translation: Low-wage security guards, you’re out of a job. K5 will now escort you from the premises.)See also: China Doubles Down On RoboticsThe robots use Wi-Fi to communicate with one another and with human operators. They include four high-definition cameras on either side of the robot, a license plate recognition camera, four microphones, and a weather sensor. Stephens did not disclose how much the K5 will cost, but noted that potential customers include security companies, office buildings, and schools. Photo of the K5 via KnightScope Why Tech Companies Need Simpler Terms of Servic… Tags:#Everyday Robots#K5#Knightscope#robocop#robot autonomy#robotics#robots#Stacy Stephens lauren orsini Top Reasons to Go With Managed WordPress Hostingcenter_img A Web Developer’s New Best Friend is the AI Wai… Related Posts 8 Best WordPress Hosting Solutions on the Marketlast_img read more

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a month agoFikayo Tomori on Chelsea screamer: I thought ‘why not?’

first_imgAbout the authorPaul VegasShare the loveHave your say Fikayo Tomori on Chelsea screamer: I thought ‘why not?’by Paul Vegasa month agoSend to a friendShare the loveFikayo Tomori has spoken of his wonder goal in Chelsea’s win at Wolves.The fullback hit a screamer for the 5-2 win.”First up Azpi was calling me back to stop the counter-attack, and the ball broke out,” he told chelseafc.com.”I thought ‘why not?’ and thankfully it managed to hit the back of the net. I’m obviously really pleased!”In training the past couple of weeks Willy Caballero’s been giving me a bit because I’ve skied a few! I just wanted to concentrate on trying to keep it down and hitting the target.” last_img

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